陳永泉_默認(rèn)分類_專家名師_食品伙伴網(wǎng)學(xué)習(xí)中心

姓名：陳永泉	性別：男
民族：未填寫(xiě)	出生年份：1962
最高學(xué)歷：研究生	學(xué)位：博士
1982年畢業(yè)于復(fù)旦大學(xué)微生物學(xué)系獲學(xué)士學(xué)位，1990年畢業(yè)于比利時(shí)Free University of Brussels分子生物學(xué)系獲博士學(xué)位，1993年在美國(guó)Wayne State University病理學(xué)系完成博士后研究后留校工作，2002-2012在美國(guó)Wake Forest University醫(yī)學(xué)院工作。2012年回國(guó)，現(xiàn)為江南大學(xué)食品學(xué)院教授及功能脂質(zhì)與健康卓越中心（Center of Excellence for Bioactive Lipid andHealth）主任。　　陳永泉教授研究方向?yàn)槭称坊钚猿煞峙c人體健康及疾病預(yù)防, 研究興趣主要集中在脂肪合成、代謝與癌癥相互關(guān)系及機(jī)制。已在國(guó)際核心期刊上發(fā)表論文95余篇, 其中近50篇發(fā)表在SCI影響因子5.0以上雜志，是本領(lǐng)域國(guó)內(nèi)外知名學(xué)者之一。作為會(huì)議主席或分會(huì)主席參加國(guó)際會(huì)議10次, 作大會(huì)報(bào)告和特邀報(bào)告66次。兼任25種英文雜志編委和審稿人, 是Frontiers in Bioscience, Nutrition and Dietary Supplements, CancerManagement and Research, Clinical Medicine: Urology, Integrative MedicineInsights編輯之一。是NIH (美國(guó)國(guó)立衛(wèi)生健康研究院), DOD (美國(guó)國(guó)防部) 等90個(gè)美國(guó)及其他國(guó)家資助機(jī)構(gòu)的評(píng)審專家組成員。曾獲得NIH P01項(xiàng)目1項(xiàng), NIHR01項(xiàng)目10項(xiàng)，從1993年來(lái),共承擔(dān)研究課題28項(xiàng),研究課題總經(jīng)費(fèi)超過(guò)4000萬(wàn)美元, 其中作為PI的超過(guò)2000萬(wàn)美元。　　【受教育經(jīng)歷】　　1990/06-1993/02 美國(guó)Wayne State University病理學(xué)系博士后　　1984/06-1989/09 比利時(shí)Free University of Brussels分子生物學(xué)系博士學(xué)位　　1978/06-1982/08 復(fù)旦大學(xué) 微生物與分子生物學(xué) 學(xué)士學(xué)位　　【研究工作經(jīng)歷】　　2012/02 – 至今江南大學(xué)，食品學(xué)院教授，功能脂質(zhì)與健康卓越中心主任　　2008/06 – 至今江南大學(xué)，長(zhǎng)江學(xué)者講座教授　　2005/06 – 至今美國(guó)Wake Forest University醫(yī)學(xué)院，終身教授　　2002/01 – 至今美國(guó)Wake Forest University脂質(zhì)研究中心，主任　　2002/01-2005/05 美國(guó)Wake Forest University醫(yī)學(xué)院，副教授　　1998/06-2002/01 美國(guó)Wayne State University病理學(xué)系，副教授　　1993/03-1998/05 美國(guó)Wayne State University病理學(xué)系，助理教授

　　1、"Mechanism of fish oil supplement in prevention of cancer"（NIH P01 CA106742），項(xiàng)目負(fù)責(zé)人，2006.03-2012.02.

　　2、"Omega-3 PUFA-gene interaction in prostate cancer"(NIH R01 CA163273)，項(xiàng)目負(fù)責(zé)人，2012.05-2017.04.

　　3、 "Effects of dietary omega-3 fatty acids on Akt signaling in prostate cancer"(NIH R01 CA107668)，項(xiàng)目負(fù)責(zé)人，2009.03-2012.02.

　　4、“Mechanisms of fish oil supplement in prevention of prostate cancer”(NIH R01 CA107668 )，項(xiàng)目負(fù)責(zé)人，2004.05-2009.04.

　　5、“Effect of dietary omega-3 fatty acid supplement on prostate cancer metastasis”(NIH R21 CA124511)，項(xiàng)目負(fù)責(zé)人，2006.03-2008.02.

　　6、“江蘇省創(chuàng)新團(tuán)隊(duì)”（省級(jí)項(xiàng)目），項(xiàng)目負(fù)責(zé)人，2012.12-2015.12.

　　7、“江蘇省雙創(chuàng)計(jì)劃”（省級(jí)項(xiàng)目），項(xiàng)目負(fù)責(zé)人，2012.11-2015.12.

　　已發(fā)表的SCI收錄論文（帶*為責(zé)任作者）

　　1. Haiqin Chen, Zhennan Gu, Hao Zhang, Wei Chen, W.Todd Lowther, Yong Q. Chen*. expression and Purification of IntegralMembrane Fatty Acid Desaturases. PLoS One, In press, 2013.

　　2. Yong Q. Chen*, editor, Animal Models of Cancer,Cancer metastasis Reviews, 32 issue 1, 2013.

　　3. Janel Suburu and Yong Q. Chen*.Polyunsaturated Fatty Acids and Cancer Prevention. In Inflammation and Cancer:Mechanisms and Dietary Approaches for Cancer Prevention (A-N. T. Kong ed.) pp,2013, Taylor and Francis Group, Boca Raton, FL.

　　4. Janel Suburu and Yong Q. Chen*. Lipid andProstate Cancer. Prostaglandins & Other Lipid Mediators, 98: 1-10, 2012.

　　5. Tim Y. Hou, Jennifer M. Monk, Yang-Yi Fan, RolaBarhoumi, Yong Q. Chen, Gonzalo M. Rivera, David N. McMurray and RobertS. Chapkin. n-3 polyunsaturated fatty acids suppressphosphatidylinositol-(4,5)-bisphosphate 1 dependent actin remodeling duringCD4+ T cell activation. Biochemical Journal 443: 27-37, 2012.

　　6. Shihua Wang, Jiansheng Wu, Janel Suburu, ZhennanGu, Jiaozhong Cai, Linara S. Axanova, Scott D. Cramer, Michael J. Thomas, DonnaL. Perry, Iris Edwards, Lorelei Mucci, Jennifer Sinnott, Massimo Loda,Guangchao Sui, Isabelle M. Berquin and Yong Q. Chen*. Effect of DietaryPolyunsaturated Fatty Acids on Castration-resistant Prostate Cancer.Carcinogenesis 33: 404-412, 2012.

　　7. M. Katie Conley-LaComb, Wei Huang, Shihua Wang,Dongping Shi, Young Suk Jung, Abdo Najy, Rafael Fridman, R. Daniel Bonfil,Michael Cher, Yong Q. Chen and Hyeong-Reh Choi Kim. PTEN Regulates PDGFLigand Switch for β-PDGFR Signaling in Prostate Cancer. Am. J. Path. 180:1017-1027, 2012.

　　8. Isabelle M. Berquin, Iris J. Edwards, SteveKridel, Yong Q. Chen*. Polyunsaturated Fatty Acid metabolism in ProstateCancer. Cancer metast. Rev. 30: 295-309, 2011.

　　9. Axanova, L. S., Chen, Y. Q., McCoy, T.,Sui, G and Cramer, S. D. 1,25-dihydroxyvitamin D3 and PI3K/AKT inhibitorssynergistically inhibit growth and induce senescence in prostate cancer cells.Prostate 70:1658-1671, 2010.

　　10. Seaho Kim, Wei Huang, Emilio P. Mottillo, AnjumSohail, Yoon-Ah Ham, M. Katie Conley-LaComb, Chong Jai Kim, Guri Tzivion,Hyeong-Reh Choi Kim, Shihua Wang, Yong Q. Chen, and Rafael Fridman.Posttranslational regulation of membrane type-1 matrix metalloproteinase(MT1-MMP) in mouse Pten-null prostate cancer cells: enhance surface expressionand differential O-glycosylation of MT1-MMP1. BBA-Mol. Cell Res. 1803:1287–1297, 2010

　　11. Heidi J. Chial, Peter Lenart, and Yong Q.Chen*. APPL proteins FRET at the BAR: Direct observation of BARdomain-mediated interactions on cell membranes. PLoS One 5:e12471, 2010

　　12. Yunping Hu, Haiguo Sun, Rick T. Owens, ZhennanGu, Jiansheng Wu, Yong Q. Chen, Joseph T O’ Flaherty, Iris J. Edwards.Syndecan-1-dependent suppression of PDK1/Akt/Bad signaling by docosahexaenoicacid induces apoptosis in prostate cancer. Neoplasia 12: 826-836, 2010.

　　13. Haiguo Sun, Yunping Hu, Zhennan Gu, Martha D.Wilson, Yong Q. Chen, Lawrence L. Rudel, Mark C. Willingham and Iris J.Edwards. Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 miceis associated with increased mammary gland and liver syndecan-1. PLoS One6:e20502, 2011.

　　14. Haiguo Sun, Yunping Hu, Zhennan Gu, Rick T Owens,Yong Q Chen and Iris J Edwards. Omega-3 fatty acids induce apoptosis inhuman breast cancer cells and mouse mammary tissue through syndecan-1inhibition of the MEK-Erk pathway. Carcinogenesis 32: 1518-1524, 2011.

　　15. Hongchao Wang, Bo Yang, Yun Feng, Guangfei Hao,Haiqin Chen, Lu Feng, Yong Q. Chen, Hao Zhang, Lei Wang, Wei Chen.Biochemical characterization of Tetrahydrobiopterin synthesis pathway in fungusMortierella alpina. Microbiology 157: 3059-3070, 2011.

　　16. Lei Wang, Wei Chen, Yun Feng, Yan Ren, ZhennanGu, Haiqin Chen, Hongchao Wang, Michael J. Thomas, Baixi Zhang1, Isabelle M.Berquin5, Yang Li2, Jiansheng Wu5, Huanxin Zhang2, Yuanda Song1, Xiang Liu7,James S. Norris, Suriguga Wang, Peng Du, Junguo Shen, Na Wang, Yanlin Yang, WeiWang, Lu Feng, Colin Ratledge, Hao Zhang, and Yong Q. Chen*. GenomeCharacterization of the Oleaginous Fungus Mortierella alpina. PLoS One, 6:e28319, 2011.

　　17. Berquin, I.M., Edwards, I.J., O’Flaherty, J.T.and Chen*, Y.Q. Omega 3 PUFAs: Interventional trials for the preventionand treatment of breast and prostate cancer. In Dietary Omega-3 PolyunsaturatedFatty Acids and Cancer (G. Calviello ed.) pp149-166, 2010, Springer, New York,NY.

　　18. Edwards, I.J., Berquin, I.M., Chen, Y.Q.and O’Flaherty, J.T. Omega-3 PUFAs, breast and prostate cancer: Experimentalstudies. In Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer (G.Calviello ed.) pp167-188, 2010, Springer, New York, NY.

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