樊振川_默認(rèn)分類(lèi)_專(zhuān)家名師_食品伙伴網(wǎng)學(xué)習(xí)中心

姓名：樊振川	性別：男
民族：漢族	出生年份：1974
最高學(xué)歷：研究生	學(xué)位：博士
個(gè)人簡(jiǎn)介　　美國(guó)奧本大學(xué)（Auburn University）博士，德克薩斯大學(xué)休斯頓醫(yī)學(xué)院（The University of Texas Health Science Center at Houston）和德州農(nóng)工大學(xué)（Texas A&M University）博士后。目前任天津科技大學(xué)“海河學(xué)者”特聘教授，博士生導(dǎo)師。研究領(lǐng)域?yàn)槭称贩肿游⑸飳W(xué)和營(yíng)養(yǎng)代謝，特別關(guān)注釀制食品微生物生物技術(shù)、新型綠色食品細(xì)胞工廠開(kāi)發(fā)、功能食品因子的高效生物生產(chǎn)以及與能量代謝有關(guān)的營(yíng)養(yǎng)代謝病機(jī)理研究等，致力于為食品生產(chǎn)、安全控制和營(yíng)養(yǎng)效價(jià)提供理論依據(jù)及技術(shù)支持途徑。

　　主持課題

　　1.小分子藥學(xué)伴侶分子功能拯救赤黑素4型受體抗肥胖的分子機(jī)理，天津科技大學(xué)海外人才引進(jìn)科研啟動(dòng)基金 (20134404110), 2013年3月到2016年2月, 50萬(wàn)元

　　論文發(fā)表（* 通訊作者）

　　1. Fan ZC*. A novel green microalgae expression system for stable and high-level production of nuclear-encoded heterologous proteins. Plant Biotechnology Journal (Submitted)

　　2. Hu Z, Ma J, Tong W, Zhu L, Fan ZC, Cronan JE and Wang HH. None of the amino acid residue ser138, tyr151 and lys155 plays a role in the catalytic action of Escherichia coli 3-ketoacyl-acyl carrier protein reductase. Biochemical Journal (Submitted)

　　3. Feng S, Yang J, Ma J, Fan ZC, Cronan JE and Wang HH. Identification and functional characterization of two 3-ketoacyl-ACP reductases in Ralstonia solanacearum. Molecular Microbiology (Submitted)

　　4. Liu Z, Wang Z, Zhao J, Wang HH and Fan ZC*. Rescue of cell-surface expression and signaling of obesity-causing melanocortin-4 G protein-coupled receptor mutants with a novel nonpeptidic small-molecule antagonist. Journal of Molecular Endocrinology (Submitted)

　　5. Wang Z, Zhong M, Wang HH, Zhao J and Fan ZC*. Restoration of the obesity-causing mutant MC4R cell surface expression and signaling in vitro by the pharmacological chaperone ML00253764. Journal of Molecular Endocrinology (Under revision)

　　6. Cheng J, Ma J, Lin J, Fan ZC, Cronan JE and Wang HH. 2012. only one of the five Ralstonia solanacearum long-chain 3-ketoacyl-ACP synthase homologues functions in fatty acid synthesis. Applied and Environmental Microbiology 78:1563-1573

　　7. Fan ZC* and Bird RC. 2012. An alternative -1/+2 open reading frame exists within Npro(1-19) region of bovine viral diarrhea virus SD-1. Virus Research 163:341-351

　　8. Fan ZC* and Bird RC. 2012. Development of a reporter bovine viral diarrhea virus and initial evaluation of its application for high throughput antiviral drug screening. Journal of Virological Methods 180:54-61

　　9. Fan ZC, Behal RH, Geimer S, Wang Z, Williamson SM, Zhang H, Cole DG and Qin H. 2010. Chlamydomonas DYF-1 is an IFT particle complex B subunit and required for flagellar assembly. Molecular Biology of the Cell 21:2696-2706

　　10. Fan ZC* and Bird RC. 2010. The extra 16-amino-acid peptide at C-terminal NS2 of the hypervirulent type-2 bovine viral diarrhea viruses has no effect on viral replication and NS2-3 processing of type-1 virus. Virus Genes 41:218-223

　　11. Fan ZC and Tao YX. 2009. Functional characterization and pharmacological rescue of human melanocortin-4 receptor mutants identified from obese patients. Journal of Cellular and Molecular Medicine 13:3268-3282

　　12. Wang Z, Fan ZC, Williamson S and Qin H. 2009. Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of the IFT complex B and physically interacts with IFT27 in Chlamydomonas. PLoS ONE 4(5):e5384

　　13. Roth CL, Ludwig M, Woelfle J, Fan ZC, Biebermann H and Tao YX. 2009. A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity. Endocrine 13:1123-1133

　　14. Fan ZC* and Wang HH. 2009. Regeneration and characterization of a recombinant bovine viral diarrhea virus and determination of its efficiency to cross the bovine placenta. Virus Genes 38:129-135

　　15. Fan ZC, Sartin JL and Tao YX. 2008. Pharmacological analyses of two porcine melanocortin-4 receptor mutants in domestic pigs. Domestic Animal Endocrinology 34:383-390

　　16. Fan ZC, Sartin JL and Tao YX. 2008. Molecular cloning and pharmacological characterization of the porcine melanocortin-3 receptor. Journal of Endocrinology 196:139-148

　　17. Fan ZC*, Dennis JC and Bird RC. 2008. Bovine viral diarrhea virus is a suitable viral vector for stable expression of heterologeous gene when inserted in between Npro and C genes. Virus Research 138:97-104

　　18. Wang SX, Fan ZC and Tao YX. 2008. Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation. Biochemical Pharmacology 154:223-230

　　19. Fan ZC* and Bird RC. 2008. Generation and characterization of an Npro-disrupted marker bovine viral diarrhea virus derived from a BAC cDNA. Journal of Virological Methods 151:257-263

　　20. Fan ZC* and Bird RC. 2008. An improved reverse genetics system for generation of bovine viral diarrhea virus as a BAC cDNA. Journal of Virological Methods 149:309-315

　　21. Ge SC, Fan ZC, Chen XS and Yang SS. 2001. Subcloning and sequencing of DNA fragment related to salt tolerance in Sinorhizobium Meliloti 042B. Acta Microbiologica Sinica 41:9-15 (中文)

　　22. Wang HH, Fan ZC and Yang SS. 2000. Screening salt tolerant mutant and salt dependent mutants of moderate Halophile B5. Journal of Shanxi Agricultural University 20:64-67 (中文)

　　23. Fan ZC, Wang HH, Ge SC and Yang SS. 2000. Identification of the promoter region in the putative tnpA of Halomonas sp. C6 by employing the reporter gene gfp. Journal of Agricultural Biotechnology 8:412-416 (中文)

　　24. Wang HH, Fan ZC, Zeng J and Yang, SS. 1999. The antibiotic resistance of a plasmid regulated by osmotic pressure from Halomonas sp. C6. Journal of Agricultural Biotechnology 7:366-372 (中文)

　　25. Wang HH, Fan ZC, Zeng J and Yang SS. 1999. Cloning and sequencing of the DNA fragment related to salt tolerance of Halomonas sp. C6. Journal of Agricultural Biotechnology 7:271-276 (中文)

　　專(zhuān)利申請(qǐng)

　　1.樊振川. 一種萊茵衣藻高效穩(wěn)定核表達(dá)載體及其表達(dá)系統(tǒng)的構(gòu)建方法 (中國(guó)專(zhuān)利，已遞交申請(qǐng))

　　2.Fan ZC. A method to perform nuclear gene knockout of Chlamydomonas reinhardtii using hybrid TALE nuclease (PCT 專(zhuān)利, 準(zhǔn)備申請(qǐng))

　　大會(huì)報(bào)告

　　1.Functional rescue of intracellularly retained human melancorotin-4 receptor mutants. 90th Annual meeting of Endocrine Society, San Francisco, California, 2008.06.18

　　2.Rescue of intracellularly-retained mutant melanocortin-4 receptors with pharmacoperone. The Epsilon Chapter Phi Zeta Research Day, Auburn University, 2007.11.07

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