1、國(guó)家自然科學(xué)基金，噠嗪并雜環(huán)衍生物的合成及抗癲癇作用研究，項(xiàng)目編號(hào)：30960458，2010.1-2012.12。課題主持人。

 

　　2、浙江省自然科學(xué)基金一般項(xiàng)目, TPY 化合物在水產(chǎn)品加工中保鮮應(yīng)用技術(shù)研究，項(xiàng)目編號(hào)：LY12C19005，2012.1-2013.12。課題主持人。

 

　　3、浙江省重點(diǎn)科技創(chuàng)新團(tuán)隊(duì)建設(shè)子項(xiàng)目，魷魚皮膠原蛋白多肽抗氧化作用在化妝品中的應(yīng)用研究，項(xiàng)目編號(hào)：2012R10029-11，2011.4-2014.4。課題主持人。

 

　　4、國(guó)家星火計(jì)劃項(xiàng)目，沿海灘涂無(wú)公害水產(chǎn)品基地環(huán)境質(zhì)量評(píng)價(jià)，項(xiàng)目編號(hào)：C2013C200295，2011.4-2015.12。課題主持人。

 

　　5、舟山市科技局計(jì)劃項(xiàng)目，聯(lián)合紫外輻射增加干魚水產(chǎn)品維生素D3含量加工工藝研究與產(chǎn)業(yè)化示范，2015C41015，2015.1-2017.12。課題主持人。

 

　　6、浙江省科技計(jì)劃項(xiàng)目（公益技術(shù)研究社會(huì)發(fā)展項(xiàng)目），天然魚肝油原料藥的篩選及新質(zhì)量標(biāo)準(zhǔn)關(guān)鍵技術(shù)研究，項(xiàng)目編號(hào)：2017C33131，2017.1-2019.12。課題主持人。

 

　　7、橫向課題，阿莫西汀工藝制備，2016.5-2016.8，課題主持人。

 

 

　　1. Li-ping Guan, Bing-yu Liu. Antidepressant-like effects and mechanisms of flavonoids and related analogues. Eur J Med Chem, 2016, 121:47-57.

 

　　2. Jian-Yin Ma, Ying-Chun Quan, Li-Ping Guan*, et al. Practical synthesis, antidepressant, and anticonvulsant activity of 3-phenyliminoindolin-2-one derivatives. Chem Biol Drug Des, 2016, 8(1): 342-451.

 

　　3. Li-ping Guan, Zhe-shan Quan. 3,4-DHQLO and Triazole and Its Related Analogues with anticonvulsant Effects. Mini Rev Med Chem, 2016, 16:323-342.

 

　　4. Xing-Hua Zhen, Ying-Chun Quan, Li-Ping Guan*. Design, synthesis and rotential antidepressant-like activity of 7-prenyloxy-2,3-dihydroflavanone derivatives. Chem Biol Drug Des, 2016, 87(6): 858-866.

 

　　5. Xing-Hua Zhen, Ying-Chun Quan, Li-Ping Guan* et al. Fucosterol, a sterol extracted from sargassum fusiforme, shows antidepressant and anticonvulsant effects. Eur J Pharmacolo, 2015, 768:131-138.

 

　　6. Shui-Lian Zhao, Zhou Peng, Xing-Hua Zhen, Li-Ping Guan* et al. Potent CDC25B and PTP1B phosphatase inhibitors:2,4,6-trihydroxylchalcone derivatives. med chem res, 2015, 24: 2573–2579.

 

　　7. Shui-Lian Zhao, Zhou Peng, Xing-Hua Zhen, Li-Ping Guan* et al. 6-Bromo-2,3-Dioxoindolin Phenylacetamide Derivatives: Synthesis, Potent CDC25B, PTP1B Inhibitors and Anticancer Activity. Lett Drug Design Discovery, 2015, 12:529-536.

 

　　8. Li-Ping Guan, Li-Ming Tang, Cheng-Yan Pan, et al. evaluation of potential antidepressant-like activity of chalcone-1203 in various murine experimental depressant models. Neurochem Res, 2014, 39:313–320.

 

　　9. Zhou Peng, Shui-Lian Zhao, Cheng-Yan Pan, Li-Ping Guan* et al. Synthesis of 2?-hydroxy-4?- isoprenyloxychalcone Derivatives with Potential Antidepressant-like Activity. Med Chem, 2014, 10: 789-799

 

　　10. Yuan Sun, Cheng-Yan Pan, Li-Ming Tang, Li-Ping Guan*. 2,4-Dihydroxychalcone derivatives as novel potent cell division cycle 25B phosphatase inhibitors and protein tyrosine phosphatase 1B inhibitors. Pharmazie, 2014, 69:257-262.

 

　　11. Li-Ming Tang, Fu-Nan Li, Li-Ping Guan * et al. Structure-based design, synthesis, and anticonvulsant activity of isatin-1-N-phenylacetamide derivatives. Med Chem Res, 2014, 23: 2161–2168.

 

　　12. L.-M. Tang, C.-Y. Pan, L.-P. Guan*. Synthesis and Anticonvulsant and Antidepressant Activity of Some 2-(6-bromo-2,3-dioxoindolin)- N-substituted Phenylacetamide Derivatives. Drug Res 2013; 63: 607–613.

 

　　13. Li-Ping Guan*, Dong-Hai Zhao, Yue Chang, et al. Design, synthesis and antidepressant activity evaluation 2?-hydroxy-4?,6?-diisoprenyloxychalcone derivatives. Med Chem Res, 2013, 22: 5218–5226.

 

　　14. Li-Ping Guan*, Dong-Hai Zhao, Yue Chang, Zheng-Shun Wen, Ling-Ming Tang, Fang-Fang Huang. Synthesis of 2,4-dihydroxychalcone derivatives as potential antidepressant effect, Arzneimittelforschung, 2013, 63: 46–51.

 

　　15. Shi-Ben Wang, Xian-Qing Deng, Yan-Ping Yuan, Zhe-Shan Quan, Li-Ping Guan*, Synthesis and evaluation of anticonvulsant and antidepressant activities of 5-alkoxytetrazolo[1,5-c] thieno[2, 3-e]pyrimidine derivatives, Eur J Med Chem, 2012, 56, 139-144.

 

　　16. Li-Ping Guan, Xin Sui, Yue Chang, Zheng-Shun Yan, Guo-Zhong Tong, You-Le Qu. Synthesis and anticonvulsant activity evaluation of 7-substituted-[1,2,4]-triazolo[4,3-f]pyramidine derivatives, Med Chem, 2012, 8(6):1076-1083.

 

　　17. Xin Sui, Ying-Chun Quan, Yue Chang, Rui-Peng Zhang, Yin-Feng Xu, Li-Ping Guan*, Synthesis and studies on antidepressant activity of 2?,4?,6?-trihydroxychalcone derivatives, Med Chem Res, 2012, 21: 1290–1296.

 

　　18. Li-Ping Guan, Rui-Peng Zhang, Yu Sun, Yue Chang, Xin Sui. Synthesis and studies on the anticonvulsant activity of 5-alkoxy-[1,2,4]triazolo[4,3-a]pyridine derivatives. Arzneimittelfor- schung, 2012, 62(8): 372-377.

 

　　獲獎(jiǎng)及專利

 

　　1.甄興華，權(quán)迎春，姜海英，關(guān)麗萍*。褐藻羊棲菜中巖藻甾醇的提取及其抗抑郁、抗驚厥活性研究。2016年“大北農(nóng)杯”第一屆全國(guó)農(nóng)林院校研究生學(xué)術(shù)科技作品二等獎(jiǎng)（中國(guó)學(xué)位與研究生教育學(xué)會(huì)農(nóng)村學(xué)科工作委員會(huì)）。

 

　　2.林必成，王亞仙，孫溢，關(guān)麗萍*。鈦鐵礦制備Fe3O4/TiO2復(fù)合物及其在光催化降解有機(jī)污染物中的應(yīng)用。2016年第八屆浙江省大學(xué)生化學(xué)競(jìng)賽三等獎(jiǎng)。

 

　　3. 關(guān)麗萍，趙東海，張磊，李大鵬，隋新，常月。黃酮類化合物的合成及抗抑郁作用研究，吉林省教育廳高校科學(xué)技術(shù)研究?jī)?yōu)秀成果獎(jiǎng)，二等獎(jiǎng)，2012年。

 

　　4. 關(guān)麗萍，全哲山，隋新。喹喔啉酮衍生物合成及抗癲癇作用，吉林省科學(xué)技術(shù)協(xié)會(huì)吉林省自然科學(xué)學(xué)術(shù)成果，二等獎(jiǎng)，2012年。

 

　　5. 關(guān)麗萍，隋新，權(quán)迎春。Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine，浙江省舟山市政府浙江省舟山市自然科學(xué)，二等獎(jiǎng)，2011年。

 

　　6. 全哲山，王清，李鎬，魏成喜，孫先宇，陳穎麗，鄧先清，關(guān)麗萍，張殿文，王啟欣，李偉，李明愛?？拱d癇候選藥物Q808的研究，吉林省科學(xué)技術(shù)，二等獎(jiǎng)，2011年。