科研情況

　　1、主要研究方向

　　主要研究方向?yàn)?ldquo;海洋功能蛋白(肽)的基礎(chǔ)理論與加工”、“海洋生物活性物質(zhì)”、“膠原物理化學(xué)特性及應(yīng)用”等。圍繞海洋生物蛋白，研究其組織結(jié)構(gòu)特征、加工體系的變異性及熱穩(wěn)機(jī)制、目標(biāo)蛋白（肽）的獲取、結(jié)構(gòu)解析與功能基因定位、生物活性及構(gòu)效評(píng)價(jià)等。

　　2、主要科研課題

　　近五年作為負(fù)責(zé)人先后承擔(dān)8項(xiàng)課題，其中國(guó)家級(jí)及省部級(jí)課題5項(xiàng)；另外作為項(xiàng)目骨干參與國(guó)家863計(jì)劃課題、支撐計(jì)劃、海洋局公益性行業(yè)專項(xiàng)等多項(xiàng)課題研究。

　　1. 教育部博士點(diǎn)基金：基于MAPK 通路的大馬哈魚皮活性肽抗皮膚光老化機(jī)制(負(fù)責(zé)人)

　　2. 山東省自然科學(xué)基金：海參體壁熱敏凝膠的自裂解特征及阻斷機(jī)制研究(負(fù)責(zé)人)

　　3. 國(guó)家自然科學(xué)基金：鱈魚皮肽對(duì)光老化皮膚基質(zhì)膠原降解的拮抗機(jī)制及活性中心結(jié)構(gòu)解析(負(fù)責(zé)人)

　　4. 山東省海洋經(jīng)濟(jì)創(chuàng)新發(fā)展區(qū)域示范項(xiàng)目子課題：海洋活性蛋白及其功能制品的開(kāi)發(fā)與產(chǎn)業(yè)化(負(fù)責(zé)人)

　　5.青島市科技計(jì)劃應(yīng)用基礎(chǔ)研究項(xiàng)目：高溫高壓海參體壁非酶凝膠劣化的干預(yù)途徑及作用機(jī)理研究(負(fù)責(zé)人)

　　6.中央高?；究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金：鱈魚免疫活性肽的制備及免疫機(jī)理研究(負(fù)責(zé)人)

　　7. 中國(guó)博士后面上基金：刺參膠原蛋白的聚集態(tài)表征及熱穩(wěn)性能研究(負(fù)責(zé)人)

　　8. 中央高校青年教師科研專項(xiàng)基金項(xiàng)目：大馬哈魚皮BIO-ANNs靶向活性肽對(duì)光老化皮膚MMPs拮抗機(jī)制研究(負(fù)責(zé)人)

　　9. 國(guó)家高技術(shù)研究發(fā)展計(jì)劃(863計(jì)劃)：高活性魚骨鈣肽螯合物制備關(guān)鍵技術(shù)研究與開(kāi)發(fā)(參與)

　　10. 國(guó)家科技支撐計(jì)劃：神經(jīng)細(xì)胞功能調(diào)節(jié)食品成分的制備關(guān)鍵技術(shù)、活性評(píng)價(jià)及其應(yīng)用(參與)

　　主要學(xué)術(shù)論文

　　共發(fā)表學(xué)術(shù)文章40余篇，其中以第一或通訊作者發(fā)表SCI/EI文章10余篇；出版專著一部。部分代表性學(xué)術(shù)文章如下：

　　1. Hu Hou, Bafang Li, Xue Zhao,Yongliang Zhuang, Guoyan Ren, Mingyan Yan, Yangpeng Cai, Xiukun Zhang, Li Chen.The effect of pacific cod (Gadus macrocephalus) skin gelatin polypeptides on UVradiation-induced skin photoaging in ICR mice. Food Chemistry, 2009, 115,945–950.

　　2. Hu Hou*, Yan Fan, Bafang Li*,Changhu Xue, Guangli Yu, Zhaohui Zhang, Xue Zhao. Purification andidentification of immunomodulating peptides from enzymatic hydrolysates ofAlaska pollock frame. Food Chemistry, 2012, 134(2), 821–828.

　　3. Hu Hou, Bafang Li, ZhaohuiZhang, Changhu Xue, Guangli Yu, Jingfeng Wang, Yuming Bao, Lin Bu, Jiang Sun,Zhe Peng, Shiwei Su. Moisture absorption and retention properties, and activityin alleviating skin photodamage of collagen polypeptide from marine fish skin.Food Chemistry, 2012, 135(3), 1432-1439.

　　4. Hu Hou, Bafang Li, Xue Zhao,Zhaohui Zhang, Pinglin Li. Optimization of enzymatic hydrolysis of Alaskapollock frame for preparing protein hydrolysates with low-bitterness. LWT-FoodScience and Technology, 2011, 44, 421-428.

　　5. Hu Hou, Yan Fan, Bafang Li,Changhu Xue, Guangli Yu. Preparation of immunomodulatory hydrolysates fromAlaska pollock frame. Journal of the Science of Food and Agriculture, 2012，92(15)，3029–3038.

　　6. Hu Hou, Xue Zhao, Bafang Li,Pinglin Li, Zhaohui Zhang, Xiaomin Shao, Weijian Pang, Xin Qu. Solid-phasemicroextraction method for the determination of volatile compounds inhydrolysates of Alaska pollock frame. International Journal of Food Properties,2013, 16, 790-802.

　　7. Hu Hou, Xue Zhao, Bafang Li,Zhaohui Zhang, Yongliang Zhuang. Inhibition of melanogenic activity by gelatinand polypeptides from pacific cod skin in B16 melanoma cells. Journal of FoodBiochemistry, 2011, 35, 1099–1116.

　　8. Hu Hou and Bafang Li.Response Surface Optimization of Enzymatic Hydrolysis of Silver Sillago(Sillago sihama) with Low Bitter Taste. International Journal of FoodEngineering, 2011, 7, Article 2.

　　9. Zhe Peng, Hu Hou*,Lin Bu, Bafang Li, Zhaohui Zhang, Changhu Xue. Non-Enzymatic softening mechanismof collagen gel of sea cucumber (Apostichopus Japonicus). Journal of FoodProcessing and Preservation. 2015, Accepted.

　　10. Hu Hou, Bafang Li, and Xue Zhao. Enzymatic hydrolysis ofdefatted mackerel protein with low bitter taste. Journal of Ocean University ofChina, 2011, 10, 85-92

　　11. Hu Hou, Bafang Li, Xue Zhao, Xiaomin Shao, Zhijuan Liu, YuxiaYan, Zhicong Wang, Yu Tao, Xia Yang. Proteins characteristics and lipidprofiles of silver sillago (Sillago sihama). IEEE, 2011, 7738-7741.

　　12. 侯虎, 孫江, 毛家楠, 李倩倩, 薛長(zhǎng)湖. 海參膠原纖維形態(tài)及膠原蛋白理化性質(zhì)研究. 現(xiàn)代食品科技, 2013, 29 (7), 1491-1495.

　　13. 侯虎, 彭喆, 蘇世偉, 陸姣含, 李八方. 基于特征粘度的鱈魚骨膠原蛋白酶解預(yù)測(cè)模型. 農(nóng)業(yè)機(jī)械學(xué)報(bào), 2014, 45 (3), 218-223.

　　14. 侯虎*，陳鐵軍, 彭喆, 張朝輝, 薛長(zhǎng)湖, 李八方. 超高壓處理對(duì)海參體壁凝膠穩(wěn)定性及其劣化的影響. 農(nóng)業(yè)工程學(xué)報(bào), 2014, 30 (22),316-322.

　　15. 侯虎, 趙雪, 張朝輝, 李平林, 李八方. 大孔聚苯乙烯吸附樹脂對(duì)鱈魚排免疫活性肽的脫鹽. 過(guò)程工程學(xué)報(bào), 2010, 10, 899-904.

　　16. 陳艷艷, 侯虎*, 陳鐵軍, 彭喆, 李八方. 基于酶?jìng)鞲衅?人工神經(jīng)網(wǎng)絡(luò)的膠原蛋白酶解監(jiān)控模型. 中國(guó)食品學(xué)報(bào)，已接受.

　　17. 彭喆，侯虎*，馮雁臨，蔡詩(shī)嫻，黃萌，張朝輝，薛長(zhǎng)湖，趙雪，李八方. 磷酸化與鈣交聯(lián)處理對(duì)刺參膠原聚集體凝膠特性的影響, 現(xiàn)代食品科技, 已接受.

　　18. 彭喆，侯虎*,陸姣含，律海倫，陳鐵軍，李八方. 刺參膠原蛋白的結(jié)構(gòu)特征與流變學(xué)及凝聚特性的耦合性研究. 中國(guó)食品學(xué)報(bào). 已接受.

　　19. 莊永亮，侯虎，林琳 (著). 魚皮魚骨膠原肽制備及生物活性研究. 北京：科學(xué)出版社，2015.

　　20. Lidong Guo, Hu Hou, Bafang Li, , Zhaohui Zhang,Shanshan Wang, Xue Zhao. Preparation, isolation and identification ofiron-chelating peptides derived from Alaska pollock skin. Process Biochemistry,2013, 48, 988-993.

　　21. Yongliang Zhuang, Hu Hou, Xue Zhao, Zhaohui Zhang, BafangLi. Effects of collagen and collagen hydrolysate from jellyfish (Rhopilemaesculentum) on mice skin photoaging induced by UV irradiation. Journal of FoodScience, 2009, 74: 183-188.

　　22. Shanshan Wang, Hu Hou, Jie Hou, Yu Tao, Yukun Lu, XiaYang, and Bafang Li. Characterization of acid-soluble collagen from bone ofpacific cod (Gadus Macrocephalus). Journal of Aquatic Food Product Technology,2013, 22, 407-420.

　　23. Yongliang Zhuang,Liping Sun, Xue Zhao, Hu Hou, BafangLi. Investigation of Gelatin Polypeptides of Jellyfish (Rhopilema esculentum)for Their Antioxidant Activity in vitro. Food Technology and Biotechnology.2010, 48(2): 222-228.

　　24. Guo, L., Harnedy, P.A., Li, B., Hou, H., Zhang, Z.,Zhao, X., FitzGerald, R. J. Food protein-derived chelating peptides:Biofunctional ingredients for dietary mineral bioavailability enhancement.Trends in Food Science & Technology, 2014, 37(2), 92-105.

　　25. Guo, L., Harnedy, P.A., Zhang, L., Li, B., Zhang, Z., Hou,H., FitzGerald, R. J. (2014). In vitro assessment of the multifunctionalbioactive potential of Alaska pollock skin collagen following simulatedgastrointestinal digestion. Journal of the Science of Food and Agriculture.

　　26. Yongliang Zhuang,Liping Sun, Xue Zhao, JingfengWang, HuHou, Bafang Li. Antioxidant and melanogenesis-inhibitory activities ofcollagen peptide from jellyfish (Rhopilema esculentum). Journal of the Scienceof Food and Agriculture, 2009, 89, 1722–1727.

　　獲獎(jiǎng)情況

　　1. 海洋科學(xué)技術(shù)獎(jiǎng)二等獎(jiǎng)(位次: 6/10), 2014.

　　2. 山東省優(yōu)秀博士論文(位次: 1/1), 2012.