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姓名：鄭高偉	性別：
民族：	年齡：
最高學(xué)歷：	學(xué)位：
2005年本科畢業(yè)于四川大學(xué)，2011年獲華東理工大學(xué)生物化工博士學(xué)位?，F(xiàn)工作于華東理工大學(xué)生物工程學(xué)院，任生物反應(yīng)器工程國家重點實驗室副研究員，許建和教授團隊主要成員之一。目前主持國家自然科學(xué)基金、“973”項目子課題、“863”計劃子課題等項目5項；在國際重要學(xué)術(shù)期刊如Curr Opin Biotechnol, Chem Commun, Adv Synth Catal, J Biotechnol等發(fā)表20篇SCI論文；申請發(fā)明專利5項，其中授權(quán)2項。　　研究方向　　(1) 生物催化劑的篩選、結(jié)構(gòu)與功能及催化機制研究；　　(2) 酶分子改造及其在醫(yī)藥化工分子合成中的應(yīng)用研究。

　　代表性論文（*通訊作者）

　　[1] Hieu-Huy Nguyen-Tran, Gao-Wei Zheng,* Xu-Hong Qian and Jian-He Xu*. Highly selecive and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1. Chem Commun 50, 2861–2864, 2014.

　　[2] Gao-Wei Zheng, Jian-He Xu*. New opportunities for biocatalysis: driving the synthesis of chiral chemicals. Curr Opin Biotechnol 22: 784–792, 2011.

　　[3] Gao-Wei Zheng, Hui-Lei Yu, Jian-Dong Zhang, Jian-He Xu. Enzymatic production of l-menthol by a high substrate concentration tolerable esterase from newly isolated Bacillus subtilis ECU0554. Adv Synth Catal 351: 405?414, 2009.

　　[4] Gao-Wei Zheng, Xu-Yun Liu, Zhi-Jun Zhang, Ping Tian*, Guo-Qiang Lin and Jian-He Xu*. Separation of enantiopure m-substituted 1-phenylethanols in high space-time yield using Bacillus subtilis esterase. RSC Adv 3: 20446–20449, 2013.

　　[5] Gao-Wei Zheng, Jiang Pan, Hui-Lei Yu, Minh-Thu Ngo-Thi, Chun-Xiu Li, Jian-He Xu. An efficient bioprocess for enzymatic production of l-menthol with high ratio of substrate to catalyst using whole cells of recombinant E. coli. J Biotechnol 150 (1): 108?114, 2010.

　　[6] Chen-Sheng Zhang, Zhi-Jun Zhang, Chun-Xiu Li, Hui-Lei Yu, Gao-Wei Zheng*, Jian-He Xu*. Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregate. Appl Microbiol Biotechnol 95: 91–99, 2012.

　　[7] Wei-Jia Zhou, Yan Ni, Gao-Wei Zheng*, Huan-Hui Chen, Zhi-Rong Zhu and Jian-He Xu*. Enzymatic resolution of a chiral chlorohydrin precursor for (R)-lipoic acid synthesis via lipase catalyzed enantioselecive transacylation with vinyl acetate. J Mol Catal B-Enzym 10.1016/j.molcatb.2013.11.005, 2013.

　　[8] Jia-Yan Liu, Gao-Wei Zheng*, Chun-Xiu Li, Hui-Lei Yu, Jiang Pan, Jian-He Xu*. Multi-substrate fingerprinting of esterolytic enzymes with a group of acetylated alcohols and statistic analysis of substrate spectrum. J Mol Catal B-Enzym 89: 41-47, 2013.

　　[9] Minh-Thu Ngo-Thi, Jin-Gang Yin, Jiang Pan, Gao-Wei Zheng*, Jian-He Xu*. Enantioselective hydrolysis of dl-menthyl benzoate by cell-free extract of newly isolated Acinetobacter sp ECU2040．Appl Biochem Biotechnol 170(8): 1974-1981, 2013.

　　[10] Gao-Wei Zheng, Hui-Lei Yu, Chun-Xiu Li, Jiang Pan, Jian-He Xu*. Immobilization of Bacillus subtilis esterase by simple cross-linking for enzymatic resolution of dl-menthyl acetate. J Mol Catal B-Enzym 70: 138?143, 2011.

　　[11] Xin Tian, Gao-Wei Zheng,* Chun-Xiu Li, Zhi-Long Wang, Jian-He Xu*. Enantioselective production of (S)-1-phenyl-1, 2-ethanediol from dicarboxyesters by recombinant Bacillus subtilis esterase. J Mol Catal B-Enzym 73 (1-4): 80–84, 2011.

　　[12] Jia-Yan Liu, Gao-Wei Zheng* and Jian-He Xu*. Improved enantioselective hydrolysis of 1-(3,4-methylenedioxyphenyl)ethyl acetate by a cold-adapted Bacillus amyloliquefaciens esterase. Biotechnol Bioprocess Eng accepted, 2014.

　　發(fā)明專利

　　[1] 許建和、鄭高偉、潘江、郁慧蕾. 枯草芽孢桿菌酯酶及其用于生產(chǎn)l-薄荷醇的應(yīng)用, 2010.09，中國，ZL200810040988.9.

　　[2] 許建和，沈乃東，鄭高偉，錢小龍，張杰，李春秀，潘江. 一種羰基還原酶及其基因和在不對稱還原羰基化合物中的應(yīng)用，2013.06，中國，ZL 201110387573.0.

　　[3] 馬宏敏，李春秀，潘江，鄭高偉，郁惠蕾，許建和. 一種羰基還原酶、基因和突變體及在不對稱還原羰基化合物中的應(yīng)用，中國，申請?zhí)枺?01210136823.8.

　　[4] 許建和，倪燕，潘江，李春秀，馬宏敏，鄭高偉，郁惠蕾. 生物催化不對稱還原制備(R)-鄰氯扁桃酸甲酯的方法，申請日：2012.04.11，國際PCT專利申請，申請?zhí)枺篜CT/CN2012/073812.

　　[5] 許建和、陳睿杰、鄭高偉、潘江、張玉軍. 一株紅球菌及其用于制備光學(xué)純(R)-6-羥基-8-氯辛酸乙酯及其他光學(xué)活性手性醇的用途，申請日：2013.06.17，中國，申請?zhí)枺?01310236252.X。

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鄭高偉